Featured Open Position

We accept around 20 – 25 PhD students per year, and you can apply for any and several group in our program at any time. Please check our Research Groups for research opportunities!

Open positions

Openings for new PhD students become available frequently in our Research Groups – usually 1 to 2 new PhD students join each research group per year. You are thus invited to apply to any of our groups at any time. Even if a research group is currently not featuring an open position, new opportunities may emerge during the application process. Positively evaluated applications remain in a candidate pool for up to 6 months to maximize your chances. Your application thus stands a good chance to be considered by your preferred group, also beyond the currently featured positions below.

Featured open positions:

The group leaders listed below are currently looking for new PhD students, and wish to fill a position soon. Please have a closer look at the project descriptions and required qualification.

Biology
Biophysics
CompBio
Chemistry
Featured Position

Jan Brugués

Self-organization of biological structures
Featured Position
Biophysics
Biology

Project Title:

Reconstitution of DNA loop extrusion and transcription dynamics in cell-free extracts.

Brief Summary:

We aim at elucidating the mechanisms that drive chromatin organization in the nucleus. We have recently provided the first direct proof of DNA loop extrusion in a cellular context by reconstituting this process on single DNA molecules in cell extracts. We also have shown that capillary forces driven by transcription factors lead to the emergence of DNA condensates, providing a new physical principle that could explain how distant DNA sequences meet to initiate and regulate transcription in the nucleus. Our assay puts us in a unique position to reconstitute complex processes such as the interplay between transcription and loop extrusion in cellular contexts, and ultimately understand the processes that organize chromatin in space and time.

Details here.

Methods to be used:

In vitro assays / Live imaging of embryos / Quantitative microscopy / Biophysical methods

Qualification of candidate:

We are currently looking for both experimental biophysicists as well as cell biologists/biochemists with interest in quantitative measurements and microscopy

More info:

For an idea of the current project please check our most recent paper on DNA loop extrusion

Anthony Hyman

Organization of Cytoplasm
Featured Position
Biology
Biophysics

Project Title:

Control of cellular noise via phase separation (joint project with C. Zechner)

Brief Summary:

Liquid condensates provide a potential mechanism to control molecular fluctuations in cells. We have recently provided a first proof of principle of this idea using theory and single-cell experiments. In this project, we want to explore this concept more broadly within physiological contexts and understand its functional implication for cellular control. The project has a highly interdisciplinary character and bridges between experimental work and theory. We welcome both theorists and experimentalists to apply.

Qualification of candidate:

Biophysics, biochemistry, single-cell biology, theoretical physics, stochastic processes

Dora Tang

Dynamic protocellular systems
Featured Position
Biology
Biophysics

Brief Summary:

Design, synthesis and characterization of dynamic protocells by cell free expression

Qualification of candidate:

Molecular Biology, Biochemistry, Biophysics

More info:

For more info, please visit the group page

Agnes Toth-Petroczy

Protein plasticity and evolution

Project Title:

Mining the dark proteome

Methods to be used:

Mass Spectrometry

Qualification of candidate:

Computational Biology, Bioinformatics, or Chemistry

More info:

Collaboration with the Andrej Shevchenko group at MPI-CBG: More Details here.

Christoph Zechner

Adaptive Biosystems

Project Title:

Control of cellular noise via phase separation (joint project with A. Hyman)

Brief Summary:

Liquid condensates provide a potential mechanism to control molecular fluctuations in cells. We have recently provided a first proof of principle of this idea using theory and single-cell experiments. In this project, we want to explore this concept more broadly within physiological contexts and understand its functional implication for cellular control. The project has a highly interdisciplinary character and bridges between experimental work and theory. We welcome both theorists and experimentalists to apply.

Qualification of candidate:

Biophysics, biochemistry, single-cell biology, theoretical physics, stochastic processes

ROLLING ADMISSION*:

Applications are welcome at any time

*Pilot phase. Please follow our Partner Program, the DIGS-BB www.digs-bb.de/join for additional opportunities.