Applications are welcome anytime.
Services & Facilities
The MPI-CBG invests extensively in Services and Facilities to allow research scientists shared access to sophisticated and expensive technologies. The Institute also develops new technologies necessary to realize the research mission. All these features are open and available for IMPRS PhD students.
In addition, the spirit of sharing extends beyond our program. The DRESDEN-concept has united a number of institutional partners to develop synergies in research, education, infrastructure, and administration.
The impressive portfolio of scientific instruments, services, and technologies available at MPI-CBG can be viewed at the Dresden Technology Portal, which is a joint database by the DRESDEN-concept partners.
Scientific Methodology & Expertise
| Group Leader | Research Fields | Methodological & Technical Expertise |
|---|---|---|
| Alexander von Appen | Biophysics, Cell Biology, | Protein biochemistry and reconstitution in membranes • Cryo-Electron Tomography • Biophysics • Proteomics to explore protein interactions including quantitative cross-linking mass spectrometry, proximity labeling • Live cell imaging |
| Jan Brugués | Biophysics, Cell Biology, Systems Biology, Theoretical Biophysics | Fluorescence spinning disk microscopy • LC-Polscope (quantitative polarization microscopy) • Femto-second laser ablation • DIC microscopy • Xenopus Laevis extract preparation • Spindle assembly and biochemistry • Fluorescence Correlation Spectroscopy • Single molecule imaging • Mathematical modeling • Image processing • Numerical simulation and analysis |
| Pierre Haas | Biophysics, Theoretical Biophysics | Theoretical Biophysics • Continuum Mechanics • Theory of Soft Matter • Mathematical Biology • Numerical modeling and data analysis |
Biophysics, Cell Biology | Super-Resolution Microscopy (STED, SMLM) • Fluorescence Correlation Spectroscopy, Single Molecule Tracking • Membrane labelling (lipids and proteins) in vivo and in vitro • Micro-Patterning of Surfaces for Control of Cell Attachment, Signaling and Differentiation • Reconstitution of Membrane Proteins in Model Membranes | |
Cell Biology, Genomics, Biophysics | BAC recombineering • Single molecule microscopy • C.elegans transgenomics • Protein expression and purification | |
Biophysics | Theory of active matter • Hydrodynamics, Continuum theories, discrete models • Stochastic processes • Numerical methods, simulation | |
Computer Science, Bioinformatics, Cell Biology, Developmental Biology | Graphical Models (Bayesian Networks/ Factor Graphs) • Deep Learning (Classification, Domain Adaptation, etc.) • Discrete Optimization • Efficient Algorithms • Software Design and Development | |
Cell Biology, Developmental Biology, Genetics | Drosophila genetics • Immunohistochemistry • laserscanning microscopy • in-vivo imaging of embryos • Electron microscopy • immuno-electronmicroscopy • Cell culture • Molecular biology and biochemistry | |
Biophysics, Cell Biology, Neurobiology | Custom tailored light microscopy • Wave optics and statistical optics • Laser micro-manipulation • Thermophoresis and diffusion systems • Animal and neuronal tissue dissection | |
Cell Biology, Developmental Biology, Biophysics | Zebrafish Genetics (Crispr KI and KO; transgenesis) • Molecular biology and cloning • Advanced live imaging (e.g. lightsheet) and electron microscopy (e.g. FIB-SEM) • Quantitative image analysis | |
Biophysics, Systems Biology, Computational Biology | Theory of complex networks • Applied topological and geometric methods • Theoretical biophysics • Theory of soft matter • Numerical methods and simulations | |
Computational Biology, Optical Engineering, Systems Biology, Computer Science | NGS sequencing and assembl • High throughput microscop • Image analysis / interpretation of microscope data sets • Customized control systems for microscopy • Algorithms and efficient use of computer hardware | |
Cell Biology, Biochemistry | Organic synthesis & chemical probe development • NMR spectroscopy • Lipid biochemistry • Photoaffinity probes • Live cell photoactivation experiments • Live cell imaging | |
| Gaia Pigino | Cell Biology, Biophysics, Computational Biology | 3D electron microscopy and various techniques for TEM (plastic embedding, high-pressure freezing, freeze substitution, negative staining, ultramicrotomy, etc.) • cryo-electron microscopy • cryo-electron tomography, sub-tomogram averaging, and single particle • correlative light- and electron-microscopy • Immunolabelling and immunogold labelling • TIRF microscopy • single molecule tracking • cell culture • flagella and cilia isolation • purification of axonemal protein components |
Biophysics | Statistical non-equilibrum physics • Stochastic processes • Monte Carlo simulations • Statistical inference • Analysis of next-generation sequencing experiment | |
Computational Biology, Computer Science, Systems Biology | mesh-free discretization schemes for partial differential equations • Bayesian bio-image analysis • parallel high-performance computing • bio-inspired computation • image-based modeling and simulation of biological processes in space and time | |
Proteomics, Lipidomics | Mass spectrometry • Shotgun lipidomic • LC-MS/MS | |
Developmental Biology, Cell Biology, Genetics | Ex vivo imaging of mammalian tissues • Quantitative microscopy • Mammalian genetics • Primary cell culture | |
Synthetic Biology, Biophysics, Materials Science | Protocell models • High pressure for soft matter • Cell free expression • Biophysical characterisation • Microfluidics | |
Developmental Biology, Bioinformatics | Light sheet microscopy • Biological image analysis • Image-based genomics • Transcriptomics | |
| Agnes Toth-Petroczy | Computational Biology, Genomics, Systems Biology | Bioinformatics • algorithm development • Computational experiments • Next-generation sequencing data analysis • Basic molecular biology: PCR, cloning, E. coli as a model system |
| Jesse Veenvliet | Developmental Biology | 3D in vitro modelling of mammalian development • Comparative (single-cell) transcriptomics • High-throughput wide-field live imaging • Embryonic stem cell culture and differentiation |
| Christoph Weber | Biophysics, Cell Biology | Phase transitions and phase separation • Hydrodynamic theories • Theory of active matter • Kinetic theory • Pattern formation and non-linear dynamics |
Computational Biology, Systems Biology, Synthetic Biology | Stochastic models of molecular networks • Statistical inference & learning • Molecular computing & nanotechnology • Signal processing & adaptive systems | |
Cell Biology, Computational Biology, Systems Biology | Synthetic biology • High resolution imaging • siRNA delivery systems for functional genomics • Image analysis and data extraction • Mathematical modeling • Systems biology, physics and theory |